Sodium butyrate ameliorates hepatic steatosis via modulating gut microbiota in fructose-exposed mice

Sodium butyrate (NaB) can regulate lipid metabolism and inhibit hepatic steatosis. This study aimed to investigate whether NaB alleviate fructose-induced steatosis via remodeling the gut microbiota evaluate anti-fatty liver mechanisms. The results showed that NaB-remodeled significantly alleviated increased plasma uric acid fructose levels. Furthermore, both abundance of Lactobacillus altered levels amino acids [upregulating gamma-amino butyric (GABA) downregulating L-glutamic L-arginine] in fructose-exposed mice. correlation analysis GABA positively correlated with abundance, might promote reduction triglyceride content. Further studies confirmed reduced deposition mouse hepatocytes induced pretreatment in vitro. These findings suggested could ameliorate by regulating microbiota.